PRC-CDC Once Had Denied Natural Bats as SARS-2 Origin..
中国当局曾否认蝙蝠为病毒病源。


世卫组织和中国的联合调查说，自然蝙蝠是本次疫情的病毒病源，实验室病源是极不可能的。一年多来，凡是持有实验室病源看法者，就会被主流科学界及其媒体以及中国方面扣上‘阴谋论’的帽子而予以封杀封口；中国方面则将其称为‘抹黑’中国的敌人。

然而，疫情在中国规模爆发初期，譬如2020-01-18及之前，中国当局主管部门（中疾控）十分明确地否认蝙蝠病源说，且语气强烈地把该说法称为‘谣言’（在中国大陆，被称为‘谣言’者往往会被封杀封闭、甚至被抓去关押）。同时，该当局说明，病毒之所以‘新’的主要依据是可以人传人，尽管他们和世卫组织联手多时说‘没证据证明人传人’、直到2020-01-20盖不住了、才公开说可人传人。

约两周后，以武汉病毒所石正丽给实验室病源扣上‘阴谋论’帽子的声明为标志，中国当局公开转变，把病源归于自然蝙蝠、抨击实验室病源说为‘阴谋论’。前后与此并行，中国当局联手世卫组织，猛烈谴责美国川普当局为防疫而采取的旅行限制措施，纵容来自中国的携带病毒的旅客把病毒传播到美国和世界各地，为其稍后开始‘甩锅’和把病毒病源归于美国和其它西方国家、提供了全球性的大规模疫情条件。直到现在，中国方面还在用美国等西方国家疫情规模很大而说病源在美国；其做法，就好比一个纵火者以邻居火势很大而说邻居是纵火者的无赖栽赃做法一样。

世卫组织和中国方面的联合调查开始前，世卫组织项目负责人发表声明做了调查结论，说病源是自然蝙蝠、说实验室病源‘极不可能’，即：调查还没开始，结论已经按中国方面需要而做好了。在联合国的历史上，就全球重大问题而做出如此公开违规的事情，恐怕是第一次。

与此并行，中国方面删除了许多疫情和病毒的档案记录。其中一个，是中科院媒体发布的武汉当地病例Wuhan-Hu-1。该病例说明，2019年11月20日，中国武汉地区就有确诊和住院护理的新冠病毒疫情发生了，而不是世卫组织和中国的联合调查报告说的2019年12月08日前、中国没有病例。这故事说明，最迟2019年09月，新冠病毒就已经在中国武汉地区规模传播了。这故事也说明，世卫组织和中国的联合调查报告涉嫌严重作弊。

该病例删除了，然而，中国方面无法删除就该病例而在国际社会发表的医学报告和论文、以及那些报告和论文所使用的病毒基因数据（按国际社会惯例，作者可以撤回论文报告，但该论文原件保留存档、读者还可以看到）。该基因数据说明：病毒含有自然病毒没有而人类特有的cct-cgg-cgg-gca四个密码子，这就足以说明新冠病毒来自实验室而不是自然蝙蝠；不同版本出现规模集中的变异，而这类变异是不可能在自然界短期出现、在实验室条件下却完全可以做到的，即这也可说明病毒来自实验室。

简而言之，本文引用的事实根据说明，本次疫情病源足够清楚：病毒来自实验室，全球规模疫情来自世卫组织和中国方面联手纵容疫情全球扩散。附后是与美国人士交流的文字。估计公开后，中国方面可能再次删除相关记录和数据，为证据存档故而拖延了三两天才于此公开发表。如下：


PRC-CDC Once Had Denied Natural Bats as SARS-2 Origin.
By Zhiyan-Le, 2021-06-25.
https://zhiyanleback.blogspot.com/p/prc-cdc-had-denied-natural-bats-as-sars.html

WHO-China joint report set natural bats, such as RaTG13, as the SARS-2 origin and stated that lab-leak (or made) as most unlikely. For more than a year, if you say that the SARS-2 origin comes from lab rather than from natural bats, you can be labeled as a conspiracy theorist. The PRC authorities have been especially doing such labeling. If you say that the PRC officials had known SARS-2 can do H2H/P2P (human-to-human/person-to-person transmission) at the pandemic early stage, the PRC authorities will title you as an enemy of anti-China.

However, right at the early time of this pandemic happening in China, the PRC authorities took bat-origin as rumors with clear acknowledge of H2H/P2P virus. Here is a PRC-CDC publication dated of 2020-01-18 and titled as [Five Rumors You Cannot Believe]:

关于武汉病毒性肺炎，这5大谣言 千万别信！
China CDC 2020-01-18
http://www.chinacdc.cn/jkzt/crb/qt/szkb_11803/jszl_2275/202001/t20200118_211265.html 
谣言4：SARS没消失过，一直寄生蝙蝠。
真相：2002年-2003年，我国暴发SARS疫情，近十多年，我国再未发现SARS病例，目前在蝙蝠体内也没有检测发现人SARS冠状病毒。
谣言5：武汉肺炎病毒为由来已久的非典类科罗纳病毒。
真相：网上盛传的“科罗纳病毒”是由coronavirus(冠状病毒)音译而来，引起武汉病毒性肺炎疫情的病原体为一种新的冠状病毒，不是SARS病毒。目前调查显示，该病毒人际间传播能力和致病性均较SARS弱。(see below, Picture 01).

It says (Google Online Translation):

Rumor 4: SARS has never disappeared, and bats have been parasitic.
The truth: The SARS epidemic broke out in my country from 2002 to 2003. In the past ten years, no SARS cases have been found in our country, and no human SARS coronavirus has been detected in bats.

Rumor 5: Wuhan Pneumonia Virus is the long-standing SARS Coronavirus.
The truth: The “Corona virus” that is widely circulated on the Internet is a transliteration of coronavirus (coronavirus). The pathogen causing the Wuhan Viral Pneumonia Epidemic is a new coronavirus, not SARS. Current investigations show that the human-to-human transmission and pathogenicity of the virus are weaker than those of SARS. #

And the PRC-CDC drawing marked a big [NO] re the bat-origin.



Note: The above record shows that the term [Wuhan Virus] or [Wuhan pneumonia] was created by PRC itself and was used for some time, not created by ex-President Trump (as so many media reported).

Note: The publication date is 2020-01-18. That is, in very early stage of this pandemic started in PRC, hot debate re SARS-2 origin was already going on among many Chinese, forcing PRC-CDC to express its views. About two weeks later, Feb.02 2020. Dr. Shi Zhengli of PRC-WIV stated that lab-made/leak is a conspiracy theory and that the SARS-2 origin is natural bats; meanwhile, Mr. Bai Chunli, President of the PRC NAS (the top boss of PRC-WIV and the like), told the US NAS that the SARS-2 origin is natural bats. Few days later, Lancet issued a co-signed letter saying the same with a strong toning to label lab-made/leak as politically motivated conspiracy theory.

Moreover, the WHO-China joint report set the first group of pandemic cases in China at Dec.08 2019. For this purpose, the PRC authorities deleted a medical record that shows a confirmed and hospitalized case is dated from Nov.20 to Nov.26 of 2019, in Wuhan City, (see below, Picture 02), meaning that, in PRC, SARS-2 virus had been spreading since Sept-2019 for the latest. And it just happened that, 2019-09-18, Wuhan City hosted a real time exercise re pandemic emergencies, for which PRC-WIV provided SARS-2 samples and test/ treatment tech/skills (this is the most likely event re SARS-2 leaks, although the leaker may not necessarily be Dr. Shi Zhengli of PRC-WIV.).

No doubt, the above record put the WHO-China joint report not hold any more, at least, its relevant date and the origin bat are knowingly misleading.


Worth noting: re the above deleted record, it has a SARS-2 genomic sequence with three versions. The alignment of its version 1 and 3 is as follows:

GenBank: MN908947,.
Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome.
https://www.ncbi.nlm.nih.gov/nuccore/MN908947
V1 (version 1): 30473 bp; V3 (version 3): 29903 bp.

On single gene level, the two versions have an identity of 98% and a gap of 570-BP (Att. Ref-01). How come, in nature, this 570-BP change happened in about 2 months? On global codon level, the two versions have an obvious difference focusing on 2nd/3rd BP and G/T genes, and G has a positive and T as a negative changing gap. See below:

Table 01:

 Global Codon Freq. Distribution re MN908947 (versions 1 &3)
V1 (10157 BP)
  1st 2nd 3rd avrg 1st 2nd 3rd avrg
A 3075 2903 3137 3038.33 30.3% 28.6% 30.9% 29.91%
C 2132 1610 1862 1868.00 21.0% 15.9% 18.3% 18.39%
G 1525 1909 2517 1983.67 15.0% 18.8% 24.8% 19.53%
T 3425 3735 2641 3267.00 33.7% 36.8% 26.0% 32.17%
V3 (9967 BP)
  1st 2nd 3rd avrg 1st 2nd 3rd avrg
A 2855 3077 3020 2984.00 28.6% 30.9% 30.3% 29.94%
C 1583 1818 2091 1830.67 15.9% 18.2% 21.0% 18.37%
G 1877 2492 1494 1954.33 18.8% 25.0% 15.0% 19.61%
T 3652 2580 3362 3198.00 36.6% 25.9% 33.7% 32.09%
Gap: V3  - V1.
  1st 2nd 3rd avrg 1st 2nd 3rd avrg
A -220 174 -117 -54.33 -1.7% 2.3% -0.6% 0.03%
C -549 208 229 -37.33 -5.1% 2.3% 2.7% -0.02%
G 352 583 -1023 -29.33 3.8% 6.2% -9.8% 0.08%
T 227 -1155 721 -69.00 2.9% -10.9% 7.7% -0.08%


Re the above two questions, the PRC provider has not given a clear explanation on how those changes happened in two months.

Importantly, both versions have 4 codon CCT-CGG-CGG-GCA, which exist in human but not in natural viruses (See: Dr. Steven C. Quay: Bayesian Analysis of SARS-CoV-2 Origin, 27 January 2021).

In short, the above deleted record and its genomic data have no direct indication on SARS-2 origin, but they do support PRC-CDC’s 2020-01-18 statement: the SARS-2 origin does not come from natural bats.


Pic.01:  Five Rumors You Cannot Believe (source: PRC-CDC, 2020-01-18)


Pic.02:  A Deleted Record 被删除的记录。

SARS2: PRC Case, 2019-11-20
Wuhan-Hu-1
https://bigd.big.ac.cn/ncov/genome/accession?q=Wuhan-Hu-1
Wuhan-Hu-1  
MN908947  
基因组信息  
病毒株名 Wuhan-Hu-1
序列号 MN908947
宿主 Homo sapiens
数据来源 GenBank
采样日期 12/30/2019
采样地点 China / Hubei / Wuhan
相关ID NC_045512, EPI_ISL_402125
序列完整度 Complete
质量评估 0/0/0/0/NO
样本提供单位  
数据递交单位 Shanghai Public Health Clinical Center & School of Public Health, Fudan University, Shanghai, China
发布时间 1/20/2020 20:04
序列  
临床信息  
年龄 41
性别 M
职业 a worker of seafood market in Wuhan
发作日期 11/20/2019
入院日期 11/26/2019
旅行史/接触史 NA
严重程度 NA
病患状态 admitted to ICU after 3 days of treatment
临床症状及潜伏天数 fever(38.4℃), Cough, Sputum production, Dizzy, Weakness, Chess tightness, Dyspnoea; Chest radiographs were abnormal with air-space shadowing such as ground-glass opacities, focal consolidation and patchy consolidation in both lungs; Computed-tomography scans of the chest revealed bilateral focal consolidation, lobar consolidation and patchy consolidation, especially in the lower lung; A chest radiograph revealed a bilateral diffuse patchy and fuzzy shadow on day 5 after admission (day 11 after the onset of
临床检测 complete blood count test, blood chemistry tests, arterial blood gas test, chest radiographs, PCR, BALF, deep meta-transcriptomic sequencing
基础病史 no history of hepatitis, tuberculosis or diabetes
其他病原菌感染 negative Bacterial culture
合并症 NA
临床用药和处理 Glucocorticoid therapy,Antibiotic therapy ,Antiviral therapy ,Oxygen therapy
生理生化指标追踪 Mild lymphopoenia (defined as less than 9 × 105 cells per ml) ; Elevated levels of C-reactive protein (41.4 mg l−1 of blood; reference range, 0–6 mg l−1) ;mild hypoxaemia with oxygen levels of 67 mm Hg
出院日期 NA
相关文献 A new coronavirus associated with human respiratory disease in China. [PMID: 32015508]
基因组变异统计  
© 2020 National Genomics Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences
No.1 Beichen West Road, Chaoyang District, Beijing 100101, China



Att. Ref 01:

NIH BLAST: MN908947: V1 x V3
Query Length: 30473 (v1)
Subject Length: 29903 (v3)
NW Score: 58571
Identities: 29896/30473(98%)
Gaps: 570/30473(1%)
Query  1      CGGTGACGCATACAAAACATTCCCACCATACCTTCCCAGGTAACAAACCAACCAACTTTC  60
                       ||  |||   ||      |||||||||||||||||||||||||||||||||
Sbjct  1               ATT-AAAGGTTT------ATACCTTCCCAGGTAACAAACCAACCAACTTTC  44
 
Query  29281  TGACCTACACAGCTGCCATCAAATTGGATGACAAAGATCCAAATTTCAAAGATCAAGTCA  29340
              |||||||||||| |||||||||||||||||||||||||||||||||||||||||||||||
Sbjct  29265  TGACCTACACAGGTGCCATCAAATTGGATGACAAAGATCCAAATTTCAAAGATCAAGTCA  29324
 
Query  29821  AATGTGTAAAATTAATTTTAGTAGTGCTATCCCCATGTGATTTTAATAGCTTCTTCCTGG  29880
              |||||||||||||||||||||||||||||||||||||||||||||||||||||||     
Sbjct  29805  AATGTGTAAAATTAATTTTAGTAGTGCTATCCCCATGTGATTTTAATAGCTTCTT-----  29859
 
Query  29881  GATCTTGATTTCAACAGCCTCTTCCTCATACTATTCTCAACACTACTGTCAGTGAACTTC  29940
                                                                          
Sbjct         ------------------------------------------------------------  
 
Query  29941  TAAAAATGGATTCTGTGTTTGACCGTAGGAAACATTTCAGTATTCCTTATCTTTAGAAAC  30000
                                        ||||                              
Sbjct  29860  --------------------------AGGA------------------------------  29863
 
Query  30001  CTCTGCAACTCAAGTGTCTCTGCCAAAGAGTCTTCAAGGTAATGTCAAATACCATAACAT  30060
                                                                          
Sbjct         ------------------------------------------------------------  
 
Query  30061  ATTTTTTAAGTTTTTGTATACTTCCTAGGAATATATGTCATAGTATGTAAAGAAGATCTG  30120
                                                                          
Sbjct         ------------------------------------------------------------  
 
Query  30121  ATTCATGTGATCTGTACTGTTAAGAAACACTTCAAAGGAAAACAACCTCTCATAGATCTT  30180
                                                                          
Sbjct         ------------------------------------------------------------  
 
Query  30181  CAAATCCTGTTGTTCTTGAGTTGGAATGTACAATATTCAGGTAGAGATGCTGGTACAAAA  30240
                                     |||||                          ||||||
Sbjct  29864  -----------------------GAATG--------------------------ACAAAA  29874
 
Query  30241  AAAGACTGAATCATCAGGCTATTAGAAAGATAAACTAGGCCTCTAACATAGTAACTTTAA  30300
              |||                      ||| | |||                          
Sbjct  29875  AAA----------------------AAAAAAAAA--------------------------  29886
 
Query  30301  CAGTTTGTACTTATACATATTTTCACATTGAAATATAGTTTTATTCATGACTTTTTTTGT  30360
                                            |||                           
Sbjct  29887  ------------------------------AAA---------------------------  29889
 
Query  30361  TTTAGCTTCTCTGTCTTCCATTATTTCAAGCTGCTAAAAATTAAAAATATCCTATAGCAA  30420
                                                 |||||  |||||             
Sbjct  29890  -----------------------------------AAAAA--AAAAA-------------  29899
 
Query  30421  AGGGCTATGGCATCTTTTTGTAAAAATAAGGAAAGCAAGGTTTTTTGATAATC  30473
                                   ||||                            
Sbjct  29900  ---------------------AAAA                              29903
V1:23581 caggtatatgcgctagttatcagactcagactaattctcctcggcgggcacgtagtgtag
V3:23581 ttatcagactcagactaattctcctcggcgggcacgtagtgtagctagtcaatccatcat



 

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